Short-Chain Naphthoquinone Protects Against Both Acute and Spontaneous Chronic Murine Colitis by Alleviating Inflammatory Responses
نویسندگان
چکیده
Ulcerative colitis (UC) is characterised by chronic, relapsing, idiopathic, and multifactorial colon inflammation. Recent evidence suggests that mitochondrial dysfunction plays a critical role in the onset recurrence of this disease. Previous reports highlighted potential short-chain quinones (SCQs) for treatment due to their reversible redox characteristics. We hypothesised recently described potent mitoprotective SCQ (UTA77) could ameliorate UC symptoms pathology. In dextran sodium sulphate- (DSS-) induced acute model C57BL/6J mice, UTA77 substantially improved DSS-induced body weight loss, disease activity index (DAI), length, histopathology. administration also significantly increased expression tight junction (TJ) proteins occludin zona-occludin 1 (ZO-1), which preserved intestinal barrier integrity. Similar responses were observed spontaneous Winnie chronic colitis, where DAI, Furthermore, potently suppressed elevated levels proinflammatory cytokines chemokines colonic explants both DSS-treated mice. These results strongly suggest or its derivatives be promising novel therapeutic approach human UC.
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ژورنال
عنوان ژورنال: Frontiers in Pharmacology
سال: 2021
ISSN: ['1663-9812']
DOI: https://doi.org/10.3389/fphar.2021.709973